September 18, 2017. Dr. Milica Radisic's lab at the University of Toronto just published a paper on using Biowire™ technology to screen kinase inhibitors. Kinase inhibitors are cancer targeting drugs, though certain ones have been identified to have cardiotoxic effects. The Radisic lab tested a set of compounds on a 2D screening assay, used an artificial neural network to select kinase inhibitors of specific interest, and then tested the selected compounds on 3D Biowire™ tissues. The research is published in Scientific Reports.
TARA Founder Uses Biowire™ and Neural Networks to Screen Kinase Inhibitors
As a result, currently 8 out of 9 drugs tested for cardiotoxicity fail in clinical trials, after spending significant time.