Cardiotype

Cardiotype

Cardiotype is TARA’s human-relevant cardiac tissue engineered from induced-pluripotent stem cells (iPSCs). It embodies the physiological hallmarks of the human heart and provides a picture of cardiac function, with both healthy and diseased models.

Measurements

With assays on Cardiotype tissues, we can measure multiple parameters to provide an integrated picture of how a new medicine can affect the human heart. Current tests based on cell culture and animal models do not accurately represent responses seen in human patients.

.Fo

Force

Cardiotype.Fo is our contractility analysis. Our tissues are suspended over a well using two polymer wires. When the tissues contract, they tug on these wires, producing a measurable deflection. We optically measure this deflection to determine parameters like force of contraction, relaxation, and beat duration, critical hallmarks of heart failure.

.Ep

Electrophysiology

Cardiotype.Ep is our electrophysiology analysis. It is based on sharp electrode recording of the intact tissue. As such, TARA can measure all aspects of the action potential including duration at 30%, 50% and 90% repolarization, mean diastolic potential and maximal upstroke velocity.

Tissue Types

Cardiotype tissues are not limited to representing healthy cardiac function. We can mature tissues on our platform to act as disease models or representations of the biology of individual patients.

Healthy

We can generate tissues representing healthy cardiac function. We can use commercial cell lines, like CD's iCell Cardiomyocytes², or your own proprietary lines.

Environmentally induced disease models

We can develop disease models utilizing compounds or experimental conditions known to induce disease states.

Genetically induced disease models

We can develop disease models utilizing mutations known to induce disease states.

Patient-derived disease models

We can develop disease models from patients with unknown cardiovascular etiology.

Contact Us

Have a question? Want to request a study with TARA? Please fill out and submit the contact form, and we’ll get back to you as soon as we can.